Determination of biodegradation performance for fabricated by MEW chitosan/PCL composite stents with in vitro tests

Authors : Yusuf Burak Bozkurt

Pages : 1128-1137

Doi:10.17714/gumusfenbil.1508489

View : 13 | Download : 24

Publication Date : 2024-12-15

Article Type : Research Paper

Abstract :Today, biodegradable implants have begun to become a serious alternative to permanent implant groups. Especially the development of polymer material technology can be an alternative to metallic medical instruments. An innovative manufacturing method for the fabricated of these polymeric implants is melt electrowriting (MEW). This innovative method, which emerged as a result of studies on the production quality of additive manufacturing technology, is used in products with smaller and more complex geometries, such as stents. It is anticipated that this method, which is particularly convenient for patient-specific implant models, will have an important place in the implant production market in the future. Within the framework of this perspective, in this study, a study was conducted on the polycarbolactone group using the MEW method. In order to improve the biodegradability character, biodegradability experiments of chitosan-doped stents were conducted in vitro. The degradation character of the samples subjected to immersion corrosion in two different media for 1, 7, 14 and 21 days was examined based on residual mass. It has been determined that chitosan reinforcement has a buffering effect and plays a retarding role on the degradation time. When the degradation rates were examined, it was determined that the polycarbolactone stent immersed in artificial body fluid for 21 days experienced the maximum mass loss of 1.6×10-2 gr. The value measured for this stent at the end of the first day was 5.8×10-4 gr. At the end of 21 days, the minimum loss was obtained for the chitosan-doped polycarbolactone stent in artificial body fluid (7.98×10-3 gr).
Keywords : Biyobozunurluk, Kitosan, Melt electrowriting, Polikarbolakton, Stents