Comparison of Some Hematological Parameters in Unipolar and Bipolar Depressive Disorder

Authors : Okan İMRE

Pages : 305-309

Doi:10.35440/hutfd.1321421

View : 61 | Download : 51

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Background: Major depressive disorder and bipolar disorder, which are the most severe types of mood disorders, are among the diseases that cause the most disability worldwide. One of the biggest challenges in providing early and effective treatment in mood disorders is the inability to make an early differential diagnosis between UD and BD. Many studies have suggested that neuroinflammation may play a role in the pathophysiology of mood disorders. Neutrophil/lymphocyte ratio insert ignore into journalissuearticles values(NLR);, platelet/lymphocyte ratio insert ignore into journalissuearticles values(PLR);, and monocyte/lymphocyte ratio insert ignore into journalissuearticles values(MLR); are relatively cheap hematological parameters recommended to measure the level of inflammation. This study aimed to examine the potential role of inflammatory processes in the pathogenesis of unipolar depressioninsert ignore into journalissuearticles values(UD); and bipolar depressioninsert ignore into journalissuearticles values(BD); by analyzing various hematologic markers, including NLR, PLR, and MLR Materials and Methods: The patient group comprised 54 individualsinsert ignore into journalissuearticles values(UD: 31, BD: 23);, while the healthy controlinsert ignore into journalissuearticles values(HC); group comprised 40 individuals. The study compared the values of hematologic markers between the groups. Results:The study found significant differences only in the levels of NLR among the analyzed hematologic markersinsert ignore into journalissuearticles values(p=0.004);. When the UD and BD groups were compared with HC separately, NLR was significantly higher in both the UD and BD groups compared to the HC groupinsert ignore into journalissuearticles values(p=0.002, p=0.015);. When UD and BD were compared with each other, there was no significant difference in terms of NLRinsert ignore into journalissuearticles values(P=0,416);. Conclusions: In our study, although there was no significant difference between BD and UD in terms of NLR, PLR and MLR, the higher NLR in both patient groups compared to HC suggests the presence of inflammation in both BD and UD patients. More evidence is needed to evaluate it as a disease-specific marker.
Keywords : Majör Depresyon, Bipolar Depresyon, hemogram, Enflamasyon, Biyobelirteç