The Effects of Body Mass Index and Blood Group on Immune Thrombocytopenia Therapy

Authors : Murat KAÇMAZ, Yavuz KATIRCILAR

Pages : 298-304

Doi:10.35440/hutfd.1321714

View : 37 | Download : 50

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Background: The effects of body mass index insert ignore into journalissuearticles values(BMI); and blood groups on immune thrombocytopenia insert ignore into journalissuearticles values(ITP); are not clearly known. This study aims to investigate the effect of BMI and blood groups on the treatment of ITP. Materials and Methods: All cases included in this study were primary ITP patients. Body measure-ments, treatment history, demographic, and laboratory data were recorded. The data obtained were analyzed after the patients were divided into groups based on BMI and blood groups. Results: The study included 68 insert ignore into journalissuearticles values(100%); cases, 53 of which were female insert ignore into journalissuearticles values(77.9%);. The median age of the cases was 44 years insert ignore into journalissuearticles values(min: 18, max: 87);. The median BMI was 28.05 insert ignore into journalissuearticles values(min: 17.6, max: 51.4);, and patients with normal weight, overweight, and obesity were found in 24 insert ignore into journalissuearticles values(35.3%);, 20 insert ignore into journalissuearticles values(29.4%);, and 24 insert ignore into journalissuearticles values(35.3%); cases, respectively. According to blood groups, 29 insert ignore into journalissuearticles values(42.6%);, 20 insert ignore into journalissuearticles values(29.4%);, 11 insert ignore into journalissuearticles values(16.2%);, and 8 insert ignore into journalissuearticles values(11.8%); cases had blood groups A, O, B, and AB, respectively. The analysis of BMI and blood groups together with demographic and laboratory variables revealed that patients with obesity had a higher mean age insert ignore into journalissuearticles values(p=0.049); and lactate dehydrogenase levels insert ignore into journalissuearticles values(p<0.001); than other BMI groups. In the analysis of treat-ment responses, it was found that using eltrombopag in the second-line treatment in the patients with normal weight group was associated with a better response than other BMI groups insert ignore into journalissuearticles values(p=0.025);. Conclusions: This is the first study to look investigate the relationship between BMI and ITP therapy. According to the results of our study, we believe that BMI should be considered in the selection of second-line therapy for ITP.
Keywords : Kan grubu antijenleri, eltrombopag, obesite, aşırı kilo