The Relationship Between Vitamin D and Left Ventricular Function in Thalassemia Major Patients

Authors : Defne Ay Tuncel, Şule Çalışkan Kamış, Begül Yağcıküpeli

Pages : 440-443

Doi:10.35440/hutfd.1566315

View : 21 | Download : 45

Publication Date : 2024-12-27

Article Type : Research Paper

Abstract :Background: Our goal was to evaluate a correlation vitamin D levels(VDL) with left ventricular function (LVF) in Thalassemia Major (TM) patients. Materials and Methods: Patients with TM who presented to the PHOC at Adana Faculty of Medicine, Health Sciences University, Adana City Training and Research Hospital(ACTRH) during June 1, 2022 and June 1, 2023, were eligible for the study. Routine investigations were performed, and data on 25-Hydroxyvitamin D (25(OH)D) levels, ferritin values, Echocardiography (ECHO) Ejection Fraction (EF), and Fractional Shortening (FS) were obtained from patient records . Results: The study included 89 patients of TM. The female ratio was 46.1% (n=41), while 53.9% were male (n=48). The cases ranged in age from one to twenty-four years, with a median of ten. Out of the cases, 84 were between the ages of 0 and 18 (94.4%), with 5 over the age of 18 (5.6%). The median ferritin level was 1497 µg/L (68-11354), VDL was 18 µg/L (3-52), EF was 66 (37-77), and FS was 36 (21-67). A significant inverse correlation was found in VDL with ferritin levels in TM patients. (p=0.026, r=-0.235). No correlation was found between VDL, EF, and FS levels in TM patients (p=0.684, r_0.44; p=0.082, r=0.185). Conclusions: An inverse relationship was observed between iron burden and VDL in patients diagno-sed with TM. Although cardiac dysfunction is a consequence of iron accumulation, this study did not reveal significant cardiac impairment in patients with low VDL. Available data do not support the direct effects of this deficiency on cardiac systolic functions. These findings highlight the importance of monitoring vitamin D status and controlling iron load in Thalassemia major patients.
Keywords : Transfüzyon bağımlı talasemi, d vitamini, kalp yetmezliği