Platelet and Erythrocyte Indices and Their Impact on Prognosis in Late Neonatal Sepsis

Authors : Halil Dolap, Doğan Köse

Pages : 97-103

Doi:10.35440/hutfd.1562572

View : 22 | Download : 32

Publication Date : 2025-03-26

Article Type : Research Paper

Abstract :Background: One of the most significant causes of mortality and morbidity in newborns is neonatal sepsis. Despite all the advancements in its diagnosis and treatment, it remains a major public health issue. This study aims to evaluate the hemogram parameters of newborns admitted to the neonatal intensive care unit (NICU) with a diagnosis of late-onset neonatal sepsis, both at the start of treatment and on the 7th day. Materials and Methods: This study was conducted in a cross-sectional manner with 89 newborns who received care and treatment for late-onset neonatal sepsis in the neonatal intensive care unit (NICU) of a university hospital between January 2017 and February 2020. Newborns between the postnatal 72nd hour and 30th day with positive blood or urine cultures were included in the study. The data of the study were obtained retrospectively in the digital environment by screening hemogram parame-ters, CRP levels, interventional procedure status, body fluid from which the culture was taken, culture result, initial treatment, follow-up and change in treatments, reason for hospitalization and mortality on the 1st and 7th days of sepsis. Results: It was determined that 58.4% of the newborns were male and 50.6% were term newborns. RBC and MCH levels on the 7th day of sepsis, MCV levels on the 1st day of sepsis, HGB, HCT and PLT levels on the 1st and 7th days of sepsis were found to be statistically significantly lower in newborns who lost their lives compared to living newborns. In addition, MPV levels on the 1st day of sepsis and CRP levels on the 1st and 7th days of sepsis of newborns who died were found to be statistically signi-ficantly higher than those of living newborns. Conclusions: As can be understood from the results, it has been proven that low RBC and MCH levels on the 7th day of sepsis, MCV levels on the 1st day of sepsis, HGB, HCT and PLT levels on the 1st day and 7th day of sepsis, and high CRP levels on the 1st day and 7th day of sepsis and MPV levels on the 1st day of sepsis should be considered as poor prognostic factors and are associated with mortality in the follow-up of newborns diagnosed with late-onset sepsis.
Keywords : Geç başlangıçlı Neonatal sepsis, Prognoz, Trombosit, Eritrosit