Neuroradiologic Findings Associated with Tuberous Sclerosis Complex: A Comprehensive Analysis of 24 Cases

Authors : Mehmet Demir, Özlem Öz, Mehmet Sinan Benzer

Pages : 32-35

Doi:10.35440/hutfd.1590541

View : 16 | Download : 33

Publication Date : 2025-03-26

Article Type : Research Paper

Abstract :Background: This study aims to comprehensively analyze the radiological findings of 24 TSC patients to determine the radiological profile of the disease and potential diagnostic and therapeutic imp-lications. Materials and Methods: This retrospective study was approved by the Ethics Committee of Harran University. A total of 24 genetically diagnosed TSC patients who underwent brain MRI between 2020-2024 were included. Imaging was performed using a 3 Tesla MRI scanner, employing T2 IDEAL, 3D T1 VIBRANT, and contrast-enhanced T1 sequences. Data were analyzed using IBM SPSS Statistics software, focusing on demographic characteristics and radiological findings. Results: The study included 24 TSC patients (14 males, 10 females) with a mean age of 8.43±10.24 years (range: 1-46 years). Cortical/subcortical tubers and subependymal hamartomas were identi-fied in all patients (100%). Radial bands were observed in 83.3%, infarctions in 50%, and corpus callosum dysgenesis in 41.6%. Subependymal giant cell astrocytoma (SGCA) was present in 12.5% of cases, while arachnoid cysts were noted in 20.8%. Conclusions: This study revealed a higher CNS involvement rate in TSC patients compared to the literature, with a higher prevalence among male patients. These findings emphasize the importan-ce of detailed radiological and clinical evaluations in understanding the disease. Changes in radio-logical findings with age and disease progression can contribute to optimizing treatment protocols.
Keywords : Tübüloz Skleroz Kompleksi, Merkezi Sinir Sistemi Tutulumu, Radyolojik Bulgular