Is Histopathological Examination After Cholecystectomy Necessary or Redundant?

Authors : Hüseyin Turap, Sabiha Nur Özmen, Bedri Burak Sucu, Fırat Canlıkarakaya
Pages : 635-640
Doi:10.35440/hutfd.1733640
View : 90 | Download : 144
Publication Date : 2025-12-25
Article Type : Research Paper
Abstract :Background: Although cholecystectomy is one of the most frequently performed surgeries in general surgical practice, the incidence of gallbladder cancer is very low. The aim of this study is to investigate whether selective histopathological examination, based on preoperative and perioperative suspicion, can replace routine examination of all specimens removed after cholecystectomy. Materials and Methods: This study was conducted retrospectively with 2,355 patients who underwent cholecystectomy and were examined histopathologically between January 1, 2015 and December 31, 2024 at Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital. Pathology results were divided into 3 groups as benign, premalignant and malignant. Results: Of the 2,355 patients included in the study, 569 (24.2%) were male and 1,786 (75.8%) were female. The average age was found to be 56.45 (minimum: 18 maximum: 98). Benign lesions were detected in 99.2% of specimens. Premalignant lesions were found in 0.6% of the remaining specimens, including 6 (0.3%) cases of low-grade dysplasia and 7 (0.3%) cases of biliary intraepithelial neoplasia (low grade). Only five (0.2%) of the patients had gallbladder cancer. Conclusions: In the pathology of 2,355 patients included in this study, premalignant lesions were detected in 0.6% and malignancy in 0.2%. In all specimens that were malignant, either preoperative imaging or operative findings predicted malignancy. In this context, we believe routine histopathological examination is unnecessary when preoperative and intraoperative imaging does not reveal any suspicious findings and when there are no special risk factors. This suggests that, as it is a common surgery, there will be a reduction in labor loss and a potential decrease in costs.
Keywords : Displazi, Histopatolojik inceleme, Kanser, Kolesistektomi, Safra kesesi

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