Investigation of Some Azo Dyes by QSAR Method and Acute Toxicity Test with Daphnia Magna

Authors : Yasemin KEŞKEK KARABULUT, Yelda YALÇIN GÜRKAN

Pages : 1110-1119

Doi:10.21597/jist.1214772

View : 103 | Download : 37

Publication Date : 2023-06-01

Article Type : Research Paper

Abstract :Azo dyes represent the most important class of textile dyes. Biotransformation of azo dyes can release aromatic amines. It is well known that some aromatic amines have genotoxic and/or carcinogenic properties. In this study, it was aimed to investigate the effects of azo dyes, which are composed of aromatic amines, and are widely used in the textile industry, on the environment using acute water toxicity test. The acute water toxicity test using Daphnia Magna was investigated experimentally and theoretically. The OECD QSAR Toolbox program, which has recently attracted attention in theoretical studies and is also used in international regulations, has been preferred. As a result of the studies, it was seen that the experimental and theoretical results gave parallel results. This study showed that theoretical studies can be substituted for experimental studies in order to reduce cost, time, and animal mortality in acute toxicity tests on Daphnia Magna. In addition, according to the results of this study, it was found by experimental and theoretical methods that Basic Yellow 28, Disperse Blue 291, and Disperse Brown 27-1 azo dye are ecotoxicologically toxic.
Keywords : Aromatik aminler, Azo boyaları, QSAR, Teorik kimya, Daphnia Magna, Ekotoksikoloji

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