Preparation, characterization and in vitro applications of morin hydrate loaded HPAC@MNPs nanocomposite

Authors : Ayşe Baran, Erdal Ertaş
Pages : 217-227
Doi:10.21597/jist.1533345
View : 52 | Download : 20
Publication Date : 2025-03-01
Article Type : Research Paper
Abstract :Cancer is a prevalent and fatal illness that claims the lives of millions of people globally every year, impacting individuals across all age groups and ethnicities. Because drugs that are used to treat cancer affect both malignant and healthy cells without discrimination, they are responsible for systemic toxicity in addition to creating major adverse effects Recently, drug delivery systems that specifically target specific sites have been developed to minimize adverse effects caused by drugs. Morin (MRN) is a flavonol-based drugs that has been the subject of substantial research that has been conducted to investigate its antiangiogenic, anti-inflammatory, anticancer, and antibacterial activities. This study included the synthesis of a product with magnetic properties by applying a layer of magnetic nanoparticles onto biocompatible activated carbon derived from the hawthorn plant. Characterization of HPAC@MNPs synthesized with magnetic nanoparticle (MNPs) of activated carbon (AC) obtained from hawthorn plant (HP) was confirmed by Fourier Transform Infrared (FTIR), Scanning Electron Microscope (SEM), dynamic light scattering (DLS) and Zeta Potential. DLS analysis calculated the average particle size of HPAC@MNPs and HPAC@MNPs-MRN to be about 105 nm and 142 nm, respectively. The drug-loaded magnetic nanocomposite was evaluated for its cytotoxic effects on MCF-7 (breast), U373 (Glioblastoma) cancer cell lines, and Human Umbilical Vein Endothelial Cells (HUVEC) healthy cell line. The MRN loading and release characteristics of HPAC@MNPs were analyzed. The results indicated that the enclosed medication exhibited a prolonged spreading time during release. In summary, the use of HPAC@MNPs magnetic nanocomposite carriers may have great potential to effectively deliver MRN drugs to specific sites.
Keywords : FTIR, HUVEC, MCF-7, U373, Aktif karbon, Nanopartikül

ORIGINAL ARTICLE URL