Phyllodes Tumors of the Breast: Clinicopathological Analysis of 35 Single-Center Cases

Authors : Burak İLHAN, Berkay KILIÇ

Pages : 387-396

Doi:10.38079/igusabder.1278840

View : 62 | Download : 42

Publication Date : 2023-09-09

Article Type : Research Paper

Abstract :Aim: This study was conducted with the aim of to evaluate demographics of patients with phyllodes tumor insert ignore into journalissuearticles values(PT);, clinical and histopathologic characteristics of tumors, and to share treatment approach to PTs from the experience of our center. Method: In the study, the demographic, clinicopathological characteristics and treatment approaches of the patients who were treated between 2006 and 2017 at the Oncology Institute, Istanbul University with the diagnosis of PT were evaluated retrospectively by examining the patient files and pathology records. Results: The median age was 39.7±11.1 years. For diagnosis, 6 patients underwent excisional biopsies, 1 patient incisional biopsy, and 27 patients core biopsies. Twenty seven patients underwent breast-conserving surgery insert ignore into journalissuearticles values(BCS);, whereas 8 patients had mastectomy. Re-excision was added to one lumpectomy, and 2 cases who had BCS were converted to mastectomy due to margin positivity. The mean PT size was 55.3 mm insert ignore into journalissuearticles values(13 mm - 210 mm);. The PT subtypes were as follows: benign insert ignore into journalissuearticles values(n=15, 42.9%);, borderline insert ignore into journalissuearticles values(n=7, 20.0%);, and malignant insert ignore into journalissuearticles values(n=13, 37.1%);. Among those with malignant PTs, 3 patients received chemotherapy insert ignore into journalissuearticles values(CT); and radiotherapy insert ignore into journalissuearticles values(RT); following mastectomy, one patient with lumpectomy had CT and RT, and 2 patients received only RT. Patients with PT were followed for an average of 70 months insert ignore into journalissuearticles values(12 months- 184 months);. Seven local recurrences insert ignore into journalissuearticles values(LR); insert ignore into journalissuearticles values(2 benign PT, 1 borderline PT, and 4 malignant PT);, 1 single distant metastasis insert ignore into journalissuearticles values(malignant PT);, and 1 LR plus distant metastasis insert ignore into journalissuearticles values(malignant PT); were observed in follow-up. Conclusion: Negative surgical margin of ≥1cm is the most important step in the management of PTs. The survival benefit of adjuvant CT or RT are contraversial and need further investigation.
Keywords : Filloides tümör, Meme cerrahisi, Lokal nüks

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