Early and late outcomes of patients who underwent en-bloc multiorgan resection in locally advanced gastric cancer and factors affecting the result

Authors : Osman AYDIN, Yiğit Mehmet ÖZGÜN, Volkan ÖTER, Muhammet Kadri ÇOLAKOĞLU, Erol PİŞKİN, Erdem KAKİL, Gökhan UÇAR, Erdal Birol BOSTANCI

Pages : 77-84

Doi:10.17941/agd.1336914

View : 45 | Download : 38

Publication Date : 2023-08-31

Article Type : Research Paper

Abstract :Background and Aims: The aim of this study is to examine the early and late results of patients with adjacent organ invasion insert ignore into journalissuearticles values(cT4b); who were operated for locally advanced gastric cancer in a high-volume center and to investigate the factors affecting survival. Material and Methods: Patients who underwent gastrectomy and en-bloc adjacent organ resection due to locally advanced gastric cancer between 2015 and 2019 were included in the study. Results: Radical gastrectomy and en-bloc additional organ resection were performed in 54 patients out of 435 patients who were operated for gastric cancer due to clinical T4b tumors. The mean age of all patients was 61.87 ± 12.67years. The median survival was found to be 16.5 insert ignore into journalissuearticles values(1 - 72); months. First-year survival was achieved in 37 insert ignore into journalissuearticles values(68.5%); patients, three-year survival in 11 insert ignore into journalissuearticles values(20.3%); and five-year survival in only 4 insert ignore into journalissuearticles values(7.4%); patients. Considering the factors affecting long-term survival, it was seen that postoperative complications affected survival significantly insert ignore into journalissuearticles values(p = 0.04);. We found that performing R1 resection insert ignore into journalissuearticles values(p = 0.001);, large tumor diameter insert ignore into journalissuearticles values(p = 0.02);, presence of lymphovascular invasion insert ignore into journalissuearticles values(p = 0.024); and presence of perineural invasion insert ignore into journalissuearticles values(p = 0.024); adversely affected long-term survival. Conclusion: Adequate lymph node dissection and en bloc R0 resection with adjacent organ are important for long-term survival in patients with clinical T4b gastric cancer. Surgery should be performed regardless of the T-stage of the tumor. In this respect, surgery performed with adequate R0 resection can be considered as an independent prognostic factor affecting survival. Other factors affecting long-term survival are lymph node metastasis, tumor size, post-operative complications, and vascular and perineural invasion.
Keywords : Lokal ileri mide kanseri, en blok multiorgan rezeksiyonu, sonuçlar

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