Evaluation of the myeloperoxidase/paraoxonase1 ratio as the determinant of dysfunctional HDL in polycystic ovary syndrome

Authors : Esin Merve EROL KOÇ, Selen YAMAN, Meryem CEYHAN, Salim NESELİOGLU, Özcan EREL, Melike DOĞANAY

Pages : 1804-1809

Doi:10.38136/jgon.1313215

View : 40 | Download : 37

Publication Date : 2023-10-01

Article Type : Research Paper

Abstract :Aim: The myeloperoxidase/paraoxonase1insert ignore into journalissuearticles values(MPO/PON1); ratio is known to reflect the dysfunctional HDLinsert ignore into journalissuearticles values(d-HDL); which is a measure of oxidative stress. This study aimed to evaluate the MPO/PON1 ratio in polycystic ovary syndromeinsert ignore into journalissuearticles values(PCOS);. Materials and Method: This prospective study included a total of 123 patients. The study group including the women with the diagnosis of PCOS insert ignore into journalissuearticles values(n=63); was compared to the control group including the healthy women insert ignore into journalissuearticles values(n=60);. Sociodemographic characteristics, and clinical features of the groups were recorded. Serum HDL level, MPO, and PON1 activities were evaluated. Results: The PCOS patients were observed to have increased MPO and decreased PON1 activities insert ignore into journalissuearticles values(p<0.0001 and p=0.007, respectively);. The d-HDL and was found to be significantly higher in PCOS patients compared to the healthy controls insert ignore into journalissuearticles values(0.56 insert ignore into journalissuearticles values(0.24); vs. 0.50 insert ignore into journalissuearticles values(0.12);, p<0.0001);. There were also significant associations between the oxidative parameters and PCOS related findings insert ignore into journalissuearticles values(p<0.05);. Conclusion: Besides the increased MPO/PON1 ratio which defined as d-HDL, the increased MPO and decreased PON1 activities also supported the increased oxidative status in PCOS patients. Our results may be considered to draw attention to oxidative stress and dyslipidemia in PCOS patients, even in the early periods of the women life.
Keywords : Disfonksiyonel HDL, MPO PON1, Oksidatif stres, PCOS