Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Authors : Suat ŞEN, Fettah ACIBUCU, Asım TEKIN, Neşe BÜLBÜL, Ekin Yiğit KÖROĞLU

Pages : 78-81

View : 33 | Download : 10

Publication Date : 2023-04-26

Article Type : Research Paper

Abstract :Introduction: Primary hyperparathyroidism insert ignore into journalissuearticles values(PHPT); is a common endocrine disorder characterized by hypercalcemia and a high or normal parathyroid hormone insert ignore into journalissuearticles values(PTH); level inconsistent with calcium. Complications caused by hypercalcemia or excess PTH in patients affect many systems. Therefore, early diagnosis of PHPT can help prevent complications and determine the treatment. Method: In our study, a total of 154 patients, 122 women and 32 men, who were diagnosed with PHPT in the Endocrinology outpatient clinic were retrospectively reviewed and evaluated in the light of the literature. Results: The mean age of the patients was 53.83±13.80 years. Detected mean values for calcium were 11.83±1.28 mg/dl, for phosphorus 2.47±0.57 mg/dl, for PTH 357.32±424.08 pg/ml, for vitamin 25OH D₃ 16.58±9.57 ng/ml, for estimated glomerular filtration rate insert ignore into journalissuearticles values(eGFR); was 99.03±23.84 ml/min/1.7 and for urinary calcium amount was 381.80±204.11 mg/24h. Bone mineral density insert ignore into journalissuearticles values(BMD); measurements were made in 64.3% insert ignore into journalissuearticles values(n: 99); of the patients, 38.4 % insert ignore into journalissuearticles values(n: 38); had osteopenia, and 42.4 % insert ignore into journalissuearticles values(n: 42); had osteoporosis. A history of urinary stones was found in 35.7% insert ignore into journalissuearticles values(n: 55); of the patients, and stone findings were found on ultrasonography in 36.1 % insert ignore into journalissuearticles values(n: 35);. In total, 37% insert ignore into journalissuearticles values(n: 57); of the cases developed nephrolithiasis as a complication. In the localization study, adenoma was detected in 76.8% insert ignore into journalissuearticles values(n: 116); of the patients by ultrasonography, while 70.7% insert ignore into journalissuearticles values(n: 106); were found positive by Tc99 sestamibi scan. The lower right part was the most commonly detected adenoma localization in both imaging. In the pathology results of the operated patients, 91.5% insert ignore into journalissuearticles values(n: 118); were reported as adenomas. In the follow-up of the operated patients, recurrence was detected in 4.6% insert ignore into journalissuearticles values(n: 6);. Conclusion: Early diagnosis and treatment of PHPT are important to prevent serious complications. The absence of serious complications in the cases in our study shows the importance of early diagnosis.
Keywords : primary hyperparathyroidism, hypercalcemia, nephrolithiasis, osteoporosis

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