Evaluation of Ventricular Repolarization Markers and Fragmented QRS in Patients with Bipolar Disorder

Authors : İbrahim YAĞCI, Ali İNALTEKİN, Muammer KARAKAYALI

Pages : 179-184

View : 36 | Download : 35

Publication Date : 2023-08-25

Article Type : Research Paper

Abstract :Aim: Bipolar disorder insert ignore into journalissuearticles values(BD); is one of the chronic psychiatric diseases. It has been reported that cardiovascular diseases are seen twice as often in patients with BD. Fragmented QRS insert ignore into journalissuearticles values(fQRS); has been found to be associated with myocardial scarring and is used as a marker of arrhythmia and mortality. Ventricular repolarization insert ignore into journalissuearticles values(VR); is often evaluated using QT interval and T wave measurement data. In our study, we aimed to evaluate fQRS, QTc interval, QT dispersion insert ignore into journalissuearticles values(QTd);, Tp-e interval, Tp-e/QT ratio results and VR, together with blood biochemistry parameter results of cases with BD. Material and Method: Our research was conducted with 51 people diagnosed with bipolar disorder and 52 healthy people as the control group. fQRS, QTc interval, QT dispersion insert ignore into journalissuearticles values(QTd);, Tp-e interval, Tp-e/QT ratio were measured using 12-lead electrocardiography insert ignore into journalissuearticles values(ECG);. The results of the data obtained from ECG and blood biochemistry parameter levels were used to compare the healthy and patient groups. Results: Tp-e interval insert ignore into journalissuearticles values(p=0.018); and Tpe/QT ratio insert ignore into journalissuearticles values(p=0.036); were found to be statistically significantly higher and total cholesterol level insert ignore into journalissuearticles values(p=0.006); lower in patients with bipolar disorder compared to the control group. Conclusion: An increased Tpe/QT ratio, along with a prolonged Tp-e interval, may be a useful marker of ventricular arrhythmia risk in individuals with fQRS BD.
Keywords : bipolar disorder, ventricular repolarization, electrocardiography, fragmented QRS