Fusidic Acid Sensitivity in Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospitaland Community-Acquired Skin and Soft Tissue Infections

Authors : Sevda Soydan, Nurşad Çifçi, Feray Ferda Şenol

Pages : 265-270

View : 35 | Download : 51

Publication Date : 2023-12-30

Article Type : Research Paper

Abstract :Aim: We aimed to detect the frequency of methicillin-resistant Staphylococcus aureus (MRSA) strains that were isolated from wound infections in our hospital, and then we want to evaluate the in vitro fusidic acid (FA) susceptibility rates of them to determine the place of FA in empirical treatment. Material and Method: A total of 110 S. aureus strains, which were isolated from wound culture samples from various services and outpatients, were included in the study. The bacteria were identified and antibiogram using our microbiology laboratory’s classical methods and VITEK 2 (Biomerieux, France) system. Methicillin sensitivity was evaluated according to Clinical and Laboratory Standards Institute (CLSI) criteria, and Fusidic acid sensitivity was assessed according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria. The data were recorded in the IBM Statistical Package for Social Sciences (SPSS) program version 17, statistical analyses were performed, and P 0.05). Sensitivity rates of FA in the outpatient clinics and services were found to be 90.2% and 94.9%, respectively, and the difference was not statistically significant (P >0.05). Methicillin-resistant Staphylococcus aureus was primarily isolated from pediatrics, orthopedics, general surgery, and otorhinolaryngology. In these units, FA sensitivities were 93.7%, 96.1%, 100%, and 100%, respectively. Conclusion: FA should be considered an effective and safe empirical treatment option in treating soft tissue and wound infections caused by community and hospital-acquired MRSA.
Keywords : fusidic acid, wound infections, methicillin resistant Staphylococcus aureu