THE SIGNIFICANCE OF QUANTITATIVE DATA FROM PET/CT IN THE COURSE OF SARCOIDOSIS AND THEIR ASSOCIATION WITH CLINICAL PARAMETERS

Authors : İnci Uslu Biner, Özlem Özmen, Berna Akıncı Özyürek, Ebru Tatcı, Yurdanur Erdoğan, Atila Gökçek

Pages : 22-28

Doi:10.24938/kutfd.1539744

View : 28 | Download : 32

Publication Date : 2025-04-26

Article Type : Research Paper

Abstract :Objectives: To examine the potential correlation between the presence of a disease outside the chest and the likelihood of recurrence or need for therapy, as well as to assess the relationship between quantitative measurements obtained from 18F-FDG PET/CT scans and clinical and laboratory markers associated with sarcoidosis. Material and Methods: 18F-FDG PET/CT images of 78 patients diagnosed with sarcoidosis were retrospectively examined. The SUV max value of the lesions with the highest uptake in the thoracic and extrathoracic regions of the disease was determined. Clinical and laboratory parameters, and SUV max values of the lesions were compared. The relationship between the detection of an extrathoracic disease and the need for treatment, and the development of recurrence was also investigated. Results: No significant correlation was found between patients with thoracic and extrathoracic disease regarding SUVmax and clinical and laboratory results (p>0.05). A significant correlation was detected between the SUVmax value of mediastinal lymph nodes and the presence of extrathoracic disease (p<0.05). The need for treatment was found to be higher in patients with high 18F-FDG uptakes of the thoracic lesions. No relationship was found between the presence of extrathoracic disease and disease stage (p=0.821) and treatment requirement (p=0.793). A correlation was found between any organ involvement and the presence of recurrent disease at follow-up (p=0.018). Conclusion: 18F-FDG uptake in lung lesions and mediastinal lymph nodes may be a guide to identify patients requiring treatment by confirming the association between disease activity and clinical stage. Additionally, detection of any organ involvement on 18F-FDG PET/CT may be a predictor of the recurrent disease at follow-up.
Keywords : 18F-FDG PET/BT, sarkoidoz, maksimum standardize edilmiş alım değeri, ekstratorasik hastalık