HYPERURICEMIA IN DIALYSIS PATIENTS AND ITS ASSOCIATION WITH LEFT VENTRICULAR MASS INDEX

Authors : Yaşar Kandur, Erkin Serdaroğlu, Aytül Noyan, Aysun Karabay Bayazıt, Mehmet Taşdemir, Sare Gülfem Özlü, Gül Özçelik, İsmail Dursun, Caner Alparslan, Meltem Akçaboy, Yesim Özdemir Atikel, Gönül Parmaksız, Bahriye Atmış, Lale Sever, Sevcan A. Bakkaloğlu

Pages : 43-48

View : 58 | Download : 44

Publication Date : 2025-04-26

Article Type : Research Paper

Abstract :Objective: Hyperuricemia leads to endothelial dysfunction and vascular stiffness; however, there are not enough studies on the effect of uric acid levels on the myocardium in pediatric dialysis patients. In this study, we aimed to investigate the relationship between uric acid levels and ventricular hypertrophy in children undergoing dialysis. Material and Methods: This multicenter retrospective study was conducted among nine centers. We retrospectively reviewed the medical records of pediatric long-term dialysis patients. Results: One hundred and thirty-one patients were enrolled in this study. The mean age was 11.7±5.0 years (range 1-19.5) (M/F=68/63). One hundred and seven patients were undergoing peritoneal dialysis (PD) and 24 patients were on hemodialysis (HD). The mean left ventricular mass index (LVMI), and the percentage of patients with left ventricular hypertrophy (LVH) were significantly higher in the hyperuricemia group (56±24 vs 42±14 g/m , p=0.001; 63.3% vs 41.9 %, p<0.001 respectively) than the normal uric acid (UA) group. The mean potassium level was significantly higher (4.6±0.6 vs 4.3±0.6 mEq/L, p=0.004), and hemoglobin lower (10.2±1.3 vs 10.9±1.0 g/dl, p=0.001) in patients with left ventricular hypertrophy than without left ventricular hypertrophy. Seven patients (9.2%) died in the hyperuricemia group, and 1 (1.8%) in the latter group. The multivariate regression analysis showed that hyperkalemia was the only parameter associated with left ventricular hypertrophy (OR:0.931, CI: 95%, 0.886-7.269, p= 0.043). Conclusion: Hyperuricemia and hyperkalemia seemed to be associated with left ventricular hypertrophy. So uric acid and potassium lowering medical treatment and dietary interventions may be considered essential for decreasing cardiac morbidity in pediatric long-term dialysis patients.
Keywords : Diyaliz, hiperürisemi, hiperkalemi, sol ventrikül hipertrofisi