EVALUATION OF THE SUCCESS OF THE SYSTEMIC IMMUNE-INFLAMMATORY INDEX IN DIAGNOSING, PREDICTING COMPLICATIONS AND MORTALITY IN PATIENTS WITH PEPTIC ULCER PERFORATION PRESENTING TO THE EMERGENCY DEPARTMENT

Authors : Özgür Kurtkulağı, Mehmet Ali Telafarlı, Özge Kurtkulağı, Ferhan Demirer Aydemir, Ahmet Onur Çelik, Mustafa Kaya

Pages : 104-110

Doi:10.24938/kutfd.1652109

View : 37 | Download : 52

Publication Date : 2025-04-26

Article Type : Research Paper

Abstract :Objective: Peptic ulcer perforation (PUP) is a severe complication of peptic ulcer disease, characterized by acute abdominal pain and systemic inflammation. The systemic immune-inflammatory index (SIII) has emerged as a promising biomarker for evaluating inflammation in various acute conditions, including PUP. This study investigates the diagnostic and prognostic value of SIII in PUP, focusing on its ability to predict complications and mortality. Material and Methods: This retrospective, single-center study included 150 PUP patients and 150 control patients who presented between January 2021 and December 2024. Data on the cases\\\' demographics, vital signs, and laboratory findings were collected. Based on clinical and postoperative findings, patients were divided into complicated (CPUP) and non- complicated peptic ulcer perforation (NCPUP) groups. Statistical analyses, including ROC curve analysis, were performed to evaluate the diagnostic accuracy and prognostic value of SIII. Results: SIII levels were significantly higher in PUP patients than controls (p<0.001). In CPUP patients, SIII levels were higher than in NCPUP patients (p<0.001). ROC analysis showed high diagnostic performance of SIII in identifying PUP (AUC=0.945, sensitivity=84.7%, specificity=96%). In predicting complications and mortality, SIII demonstrated moderate diagnostic accuracy (AUC=0.693 and AUC=0.745, respectively). In gastric PUP cases, complication rates were higher, and mortality was associated with increased SIII, neutrophil-lymphocyte ratio, and decreased lymphocyte- neutrophil ratio. Conclusion: SIII is a reliable biomarker for the diagnostic success of PUP and for predicting complications and mortality. Its integration into clinical practice could improve patient management and outcomes. Further studies are needed to validate these findings in larger populations.
Keywords : Peptik ülser perforasyonu, sistemik immün inflamatuvar indeks, acil servis, komplikasyon