THE COMPARISON OF PAPP-A RESULTS AND BIRTH PARAMETERS IN NORMAL PREGNANCIES WITHOUT COMPLICATIONS AND IN PREGNANCIES WITH MECONIUM

Authors : Merve Didem Eşkin Tanrıverdi, Esin Merve Erol Koç, Aytekin Tokmak, Necati Hançerlioğulları
Pages : 301-305
Doi:10.24938/kutfd.1695281
View : 39 | Download : 78
Publication Date : 2025-12-25
Article Type : Research Paper
Abstract :Objective: In the present study, we compare first and second trimester screening test parameters in uncomplicated pregnancies with those in pregnancies complicated by meconium to assess their impact on birth outcomes. This analysis may uncover the potential of maternal serum pregnancy-associated plasma protein-A and alpha-fetoprotein levels as useful markers for meconium-stained amniotic fluid, thereby enhancing clinical strategies and monitoring approaches. Material and Methods: The current study had a retrospective case-control design. In the study, a total of 1238 pregnant women were screened, and 528 who had both double and triple screening results were included. Results: Pregnant women with meconium-stained amniotic fluid exhibited significantly different biomarker levels compared to those without. Specifically, the pregnancy-associated plasma protein A MoM levels were 0.9±0.1 versus 1.2±0.2 (p=0.012), and the alpha-fetoprotein MoM levels were 1.3±0.5 versus 0.9±0.0 (p=0.009), respectively. Fetal distress rates differed significantly between pregnant women with and without meconium-stained amniotic fluid, with 11 cases (10%) compared to 10 cases (2.4%) respectively (p=0.001). The requirement for neonatal intensive care was statistically significantly higher in pregnancies with meconium-stained amniotic fluid (n=30 (27.3%) vs. n=61 (14.6%), p=0.02). Conclusion: Our study demonstrates that decreased maternal serum pregnancy-associated plasma-protein-A MoM levels, coupled with increased maternal serum alpha fetoprotein MoM levels are associated with meconium-stained amniotic fluid.
Keywords : Mekonyumla boyanmış amniyotik sıvı, PAPP-A, AFP, fetal distres, maternal serum tarama testleri

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