WAS IMMUNOGLOBULINS EFFECTIVE IN DISEASE SEVERITY AND LENGTH OF HOSPITAL STAY IN CHILDREN WITH THE INFECTION OF SARS-COV-2 ?

Authors : Hatice UYGUN, Sibel YAVUZ, Nurettin ERDEM, Saniye Başak OKTAY, Mehmet TURĞUT

Pages : 322-326

Doi:10.18229/kocatepetip.1162663

View : 39 | Download : 65

Publication Date : 2023-07-13

Article Type : Research Paper

Abstract :OBJECTIVE: We investigated whether immunoglobulin levels on admission are associated with disease severity, time to negativization of SARS-CoV-2 RT-PCR test, and length of hospital stay in children with severe illness requiring hospitalization. MATERIAL AND METHODS: Forty-four pediatric patients hospitalized and treated for COVID-19 were included. The patients were divided into two groups as those with mild-to-moderate insert ignore into journalissuearticles values(n=35); and those with severe disease insert ignore into journalissuearticles values(n=9); for ease of evaluation. The relationship of immunoglobulin levels with disease severity, time to SARS-CoV-2 RT-PCR test negativization and length of hospital stay was examined. RESULTS: The study population had a median insert ignore into journalissuearticles values(min-max); age of 13 insert ignore into journalissuearticles values(1-18); years and consisted of 25 insert ignore into journalissuearticles values(56.8%); girls and 19 insert ignore into journalissuearticles values(43.2%); boys. IgG levels were normal in 89.2% insert ignore into journalissuearticles values(n=33); and elevated in 5.7% insert ignore into journalissuearticles values(n=2); of the children with mild-to-moderate disease. Among patients with severe disease, IgG levels were normal in 44.4% insert ignore into journalissuearticles values(n=4); and elevated in 55.6% insert ignore into journalissuearticles values(n=5);. A significant difference was found between the groups in terms of IgG levels insert ignore into journalissuearticles values(p=0.002);. When the relationship of IgG level with length of hospital stay and time to SARS-CoV-2 RT-PCR test negativization was investigated, no significant correlation was observed between time to SARS-CoV-2 RT-PCR test negativization and Ig G level insert ignore into journalissuearticles values(p=0.096, z=1.667);. However, the length of hospital stay was significantly longer in patients with elevated IgG levels insert ignore into journalissuearticles values(p=0.096, p=0.002);. CONCLUSIONS: Higher-than-normal endogenous IgG levels may be independently associated with the development of severe illness and prolonged hospital stay in children hospitalized for COVID-19.
Keywords : COVID 19, Çocuk, İmmünoglobulinler