Evaluation Of The Frequency Of Vitamin D Deficiency And Its Relationship With Disease Involvement In Patients With Systemic Sclerosis

Authors : Kezban ARMAGAN, Özgül SOYSAL GÜNDÜZ

Pages : 10-16

Doi:10.35514/mtd.2023.82

View : 17 | Download : 21

Publication Date : 2023-04-30

Article Type : Research Paper

Abstract :Objective: Systemic sclerosis insert ignore into journalissuearticles values(SSc); is a chronic autoimmune disease characterized by vasculopathy, visceral and cutaneous fibrosis. Vitamin D has various functions in the immunological system and different studies have shown a potential role in triggering autoimmune diseases. Patients with SSc may present with low serum vitamin D levels, but the relationship between low vitamin D levels and disease and clinical manifestations is still unclear. Our aim is to determine the frequency of vitamin D deficiency in patients with scleroderma and to analyze the relationship between vitamin D concentration and organ involvement of systemic sclerosis. Material and Methods: This study retrospectively scanned the files of 54 patients with systemic sclerosis and compared them with the control group. Serum levels of 25-hydroxyvitamin D were measured and the two groups and Systemic sclerosis subgroups were compared. Systemic sclerosis subgroups were also analyzed for organ involvement. Results: Fifty-four SSc patients insert ignore into journalissuearticles values( 49 females, mean age 53.25 ± 10.77 years, and the median disease duration 8 insert ignore into journalissuearticles values(1-25); years); and 50 controls insert ignore into journalissuearticles values(45 females, mean age 51.02 ± 9.14 years); were included. In the Systemic sclerosis group, 7 patients insert ignore into journalissuearticles values(12.9%); had severe vitamin D deficiency insert ignore into journalissuearticles values(<5 ng/ml); and 46 patients insert ignore into journalissuearticles values(85.1%); had vitamin D deficiency insert ignore into journalissuearticles values(20 - 5 ng/ml);, while optimal vitamin D level was not found. There was a significant decrease in vitamin D in the patient group compared to the healthy control insert ignore into journalissuearticles values(p=0.001);. There was no significant difference in the analysis of Systemic sclerosis subgroups except for pulmonary involvement insert ignore into journalissuearticles values(p=0.019); and DLCO insert ignore into journalissuearticles values(p=0.023);.The correlation between 25-hydroxyvitamin D concentration and age, acute phase reactants, autoantibody profile, degree of skin involvement, disease activity and respiratory tests and vitamin D was not found. Conclusion: Serum vitamin D concentrations of patients with SSc were significantly lower than healthy controls. There was no significant correlation between skin involvement, disease activity and 25-hydroxyvitamin D level.
Keywords : Sistemik skleroz, 25 hidroksivitamin D, cilt tutulumu, pulmoner tutulum