The Effects of Diet and Microbiota on Attacks in Familial Mediterranean Fever

Authors : M Gizem KESER, Nurhan UNUSAN

Pages : 206-212

Doi:10.53394/akd.1010790

View : 17 | Download : 17

Publication Date : 2023-05-01

Article Type : Review Paper

Abstract :Familial Mediterranean fever insert ignore into journalissuearticles values(FMF); is one of the common autoinflammatory diseases with autosomal inheritance. It is more common, especially in certain European ethnic groups, and is seen frequently in Turks, North Africans, Arabs, Jews, and Armenians. In our country, the prevalence varies between 1/400 and 1/1000. In the pathogenesis, there is a mutation in the MEFV gene, composed of 10 exons and localized at the 16p13.3 chromosome. A 781 amino acid protein is encoded by insert ignore into journalissuearticles values(pyrine or marenostrin); the MEFV gene and regulates intranuclear peptide transcription when inflammation occurs. Clinically, FMF is characterized by pronounced acute phase response insert ignore into journalissuearticles values(leukocytosis, high erythrocyte sedimentation rate, C reactive protein, serum amyloid, fibrinogen); accompanied by recurrent fever and symptoms. Although the reasons that stimulate and terminate attacks are not known exactly, several factors such as infection, menstruation, surgical intervention, cold climatic conditions, a high-fat diet, and excessive physical activity can trigger attacks. In a small number of studies, it has been examined that the species that dominates the microbiota of individuals with FMF is also different from the microbiota patterns of healthy individuals. The purpose of this study is to evaluate some factors that affect the attacks’ frequency and duration in individuals with FMF, especially diet patterns.
Keywords : Ailesel Akdeniz Ateşi, Beslenme, Diyet