Association between serum netrin-1 level and obesity-related markers in obese subjects

Authors : Çiğdem AYDIN ACAR, Niyazi AYDIN, Suray PEHLİVANOĞLU, Mehmet KÖK

Pages : 108-115

Doi:10.24998/maeusabed.1130028

View : 22 | Download : 13

Publication Date : 2022-08-26

Article Type : Research Paper

Abstract :Netrins are important signaling proteins that guide both neural and vascular development. Netrin-1 regulates many physiological processes such as cell proliferation, adhesion and migration. The aim of this study was to determine the association between serum netrin-1 level and biochemical parameters in obese subjects. Serum samples were collected from obese insert ignore into journalissuearticles values(n=15); and control insert ignore into journalissuearticles values(n=30); subjects. The serum netrin-1 levels were evaluated by ELISA. Variable data were compared by Mann Whitney U test and correlation was estimated by Spearman correlation analyses. The level of circulating netrin-1 protein was determined to be significantly lower in obese group compared to controls. The median value was 844.0 pg/mL in the control group and 338 pg/mL in the obese group insert ignore into journalissuearticles values(p<0.0001);. Serum netrin-1 level was negatively correlated with HbA1c, LDL, cholesterol and triglyceride insert ignore into journalissuearticles values(P< 0.01);. In addition, ROC curve analysis indicated that netrin-1 level could define the presence of obesity with AUC value of 0.8667 insert ignore into journalissuearticles values(95% Cl=0.7249-1.000; P<0.0001);. Our study suggests that netrin-1 secretions are significantly reduced in obese subjects and negatively correlated with obesity markers. Therefore, netrin-1 can be evaluated as a possible potential biomarker for obesity.
Keywords : Obezite, Netrin 1, ELISA, Biyobelirteç