In Vitro Antibiotic Susceptibility and Species Distribution of Uropathogenic Agents Isolated from Urine Cultures

Authors : Nurnehir Baltacı Bozkurt, Ali Öztürk, Tuğba Avan Mutlu

Pages : 212-220

Doi:10.47572/muskutd.1694414

View : 81 | Download : 133

Publication Date : 2025-12-29

Article Type : Research Paper

Abstract :Urinary tract infections (UTIs) are among the most common infections in all age groups. The aim of this study was to evaluate etiologic agents, determine antimicrobial resistance rates, and review empirical treatment recommendations in urinary tract infections in a tertiary care hospital. Among the urine samples sent to the microbiology laboratory of our hospital from various units between January 2018 and October 2021, those with pyuria and significant bacteriuria in cultures were included in the study. VITEK 2 (BioMérieux, France) was used to identify the species of bacteria, and antibiotic susceptibilities were determined. The results were evaluated according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) standards. The study included 8516 patients. Escherichia coli 66.4% (n=5652), Klebsiella pneumoniae 7.8% (n=662), and Enterococcus spp. (6.5% (n=553) were isolated from urine samples, respectively. The highest antibiotic resistance was observed against E. coli with cefepime (46.7%), ampicillin (44.6%), and piperacillin (39.4%). Other Gram-negative and Gram-positive uropathogenic strains found in the study exhibited generally high susceptibility to the assessed antibiotics. The results of our research indicated that E. coli strains isolated from UTI patients exhibited a lower sensitivity to ampicillin, piperacillin, cefepime, ceftriaxone, ceftazidime, and cefuroxime axetil. Antibiotic resistance rates of UTI agents vary according to regions. Therefore, regional resistance should be taken into account when selecting treatment to improve outcomes and reduce the development of resistance in UTIs.
Keywords : Antimikrobiyal Duyarlılık, Bakteriüri, İdrar Yolu Enfeksiyonu, Üropatojen

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