Acute Outcomes and Cardiac Functions in Severe COVID-19

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Muş Alparslan Üniversitesi Sağlık Bilimleri Dergisi
Cilt: 5 Sayı: 2
Acute Outcomes and Cardiac Functions in Severe COVID-19

Acute Outcomes and Cardiac Functions in Severe COVID-19

Pages : 20-30

View : 29 | Download : 32

Publication Date : 2025-07-31

Article Type : Research Paper

Abstract :Background: Severe COVID-19 is linked to cardiovascular complications from systemic inflammation and coagulation disorders. Addressing long-term COVID effects requires knowledge of its short-term cardiovascular impacts to enhance patient management and minimize adverse outcomes. Objective: This study aimed to compare acute cardiac outcomes and function in severe versus non-severe COVID-19 patients, focusing on cardiovascular complications and prognostic implications. Material and Methods: A cross-sectional study from May to July 2021 at a tertiary care facility included 216 participants, split evenly into two groups of 108: severe and non-severe cases, matched by age and sex. The severe group required hospitalization or ICU care, while the non-severe group was treated outpatient. Evaluations included echocardiographic assessments, 12-lead electrocardiograms, and lab tests for cardiac biomarkers. Results: Patients with severe conditions had an average age of 63.7 years, compared to 58.4 years for those with no severe conditions (p < 0.001). They also showed a higher prevalence of comorbidities such as diabetes (54.6% vs. 27.8%) and hypertension (39.8% vs. 25.0%, p < 0.05). Echocardiography indicated a reduced left ventricular ejection fraction (LVEF) of 42.5% versus 60.0% (p < 0.001) and an increased E/Em ratio of 14.5 compared to 10.0 (p < 0.001) among the groups. Right ventricular dimensions were larger, measuring 4.1 cm versus 3.0 cm (p < 0.001), with a higher myocardial performance index of 0.58 vs. 0.40 (p < 0.001). Severe cases had a mortality rate of 39.8% compared to 2.8% in no severe cases (p < 0.001). Conclusion: Severe COVID-19 significantly impairs cardiac function, necessitating comprehensive cardiovascular evaluation and targeted interventions to improve outcomes
Keywords : COVİD-19, Kardiyak fonksiyonlar, Ekokardiyografi, Ölüm

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